Symptom Grade Grade 1 ALT or AST > ULN – 3x ULN Grade 2 ALT or AST 3 – 5x ULN Grade 3 ALT or AST 5 – 20x ULN Grade 4 ALT or AST > 20x ULN

Symptom Grade Grade 1 Creatinine 1.5 x baseline or > ULN-1.5x ULN Grade 2 Creatinine > 1.5 – 3x baseline or > 1.5 – 3x ULN Grade 3 Creatinine > 3x baseline or > 3 – 6x ULN Grade 4 […]

Symptom Grade Grade 1 Asymptomatic; clinical or diagnostic observations only; intervention not indicated Grade 2 Symptomatic; thyroid suppression therapy indicated; limiting instumental ADL Grade 3 Severe symptoms; limiting self-care ADL; hospitalization indicated Grade 4 Life treatening consequences; urgent intervention indicated […]

Hyperthyroidism related to immune checkpoint therapy is generally transient and followed by a phase of hypothyroidism where adequate subsitition is indicated. Therefore no causative treatment with antithyroid drugs is indicated. Note: High dose corticosteroids (1 mg/kg/day) are not routinely required […]