Evaluation Screen for new-onset diabetes Or worsening of pre-existing diabetes Assessment and Investigations Repeat fasting glycemia within one week Management Subcutaneous Insulin therapy Continue ICPI once adequate glycemic control

Assessment and Investigations Adrenalitis Unlikely 8 am or random cortisol >160 µg/L Possible 8 am cortisol 70-160 µg/L Or random cortisol 30-160 µg/L Likely 8 am cortisol <70 µg/L Or random cortisol <30 µg/L Management Await hormonal assessment (<24h) Start […]

Assessment and Investigations Adrenal crisis, rule out sepsis Adrenalitis Unlikely Random cortisol >160 µg/L Likely Random cortisol <160 µg/L Management Urgent hydrocortisone stress dose of hydrocortisone 100mg IV (or IM) Intravenous hydration Hold ICPI Taper to physiological substitution in consultation […]

Assessment and Investigations Hypophysitis Unlikely 8 am or random cortisol >160 µg/L Possible 8 am cortisol 70-160 µg/L Or random cortisol 30-160 µg/L Likely 8 am cortisol <70 µg/L Or random cortisol <30 µg/L Management Await hormonal assessment (<24h) Start […]

Assessment and Investigations Hypophysitis Unlikely Random cortisol >160 µg/L Likely Random cortisol <160 µg/L Rule out mass-effect symptoms of hypophysitis, adrenal crisis, rule out sepsis Perform MRI of the pituitary gland + whole brain imaging (exclude metastasis) Management Urgent hydrocortisone […]

ICI: Immune Checkpoint Inhibition TKI: Tyrosine Kinase Inhibition AE: adverse event Note: This is not a diagnosis/management tool for patients. Patients should always consult their treating specialist.