Skin toxicity – Grade 2-4
May 11, 2025Hepatitis – Grade 2
May 11, 2025Hepatitis
Assessment and investigations
- Review medications: e.g. statins, antibiotics, alcohol history and alternative medicines (herbs)
- Perform liver screen: – Hepatitis A/B/C serology – Hepatitis E PCR – Anti-ANA/SMA/LKM/SLA/LP/LCI – Iron studies
- Consider imaging for metastases/portal trombosis
Symptom Grade 1
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ALT or AST > ULN – 3x ULN
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Bilirubin normal (or unchanged to baseline)
Symptom Grade 2
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ALT or AST 3 – 5x ULN
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Bilirubin < 3x ULN
Symptom Grade 3
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ALT or AST 5 – 20x ULN
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Bilirubin > 3x ULN
Symptom Grade 4
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ALT or AST > 20x ULN
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Bilirubin >10x ULN