General principles

Types of AEs:

• most frequent overlapping AEs: fatigue, diarrhea, hepatotoxicity, endocrine toxicity and skin reactions
• see image below: overview of typical AEs with TKI and ICI, adapted from McGregor et al 2021 Cancer Treatment Reviews

Timing of AE:

• TKI: usually early (< weeks) after treatment initiation and quick to regress following dose hold
• ICI: unpredictable, can be months after treatment discontinuation

Management principles:

• according to CTCAE v5.0 grade and probable culprit

grade 1	mild: a- to paucisymptomatic	no intervention required
grade 2	moderate: minimal symptoms	local/non-invasive treatment
grade 3	severe: important symptoms, hospitalisation required	medical treatment
grade 4	life threatening	urgent intervention

• treatment options: