Muscle pathology – Patient stable – Severe Yes
October 29, 2026Myocarditis algorithm – Stable patient - Severe - No
Non-severe and smoldering definitive
- Withhold ICI
- Prednisone 1 mg/kg
- + reassess troponin levels after +/- 24 and 48h
No response at 48 h: reassess then escalate to 1–2 mg/kg and/or add ruxolitinib or MMF
Slow taper if improving
Isolated Troponin
of unknown significance
- Seek alternative diagnosis
- Consider withholding ICI pending diagnosis
- Repeat CK and troponin I or T in 24 h
Monitor troponin levels at each subsequent ICI cycle.