Assessment and Investigations

Hypophysitis Unlikely

• 8 am or random cortisol >160 µg/L

Possible

• 8 am cortisol 70-160 µg/L

• Or random cortisol 30-160 µg/L

Likely

• 8 am cortisol <70 µg/L

• Or random cortisol <30 µg/L

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Management

• Await hormonal assessment (<24h)
• Start physiological substitution with hydrocortisone 10-5-5mg if hypophysitis possible or likely
• Continue ICPI once adequately substituted